A Healthy Diet in Preventing and “Controlling” Cancer.

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If the verbiage of this scientific study weighs you down, jump to the end of the article and take a look at a sample, one-day “healthy” eating regime. Think & Commit to good health and well being through regular exercise and a healthy diet. And remember, TV-promoted diets are NOT THE ANSWER!

Researchers from Singapore and the UK have discovered a new mechanism that deactivates genes which suppress tumors, shedding light on why an unhealthy diet or uncontrolled metabolic conditions like diabetes can raise the risk of cancer.

Using mouse models, human tissue, and lab-grown human breast organoids, the team found that changes in glucose metabolism could promote cancer by temporarily disabling the BRCA2 gene, which normally protects against tumors.

“This study highlights how diet and weight management impact cancer risk,” explained Li Ren Kong, a cancer pharmacologist at the Cancer Science Institute of Singapore (CSI Singapore) and lead author of the study. “Initially, we aimed to understand factors elevating cancer risk in susceptible families but uncovered a deeper link between energy metabolism and cancer development.”

Their findings challenge the long-standing ‘two-hit’ theory by Knudson from 1971, which posited that both copies of a tumor suppressor gene must be permanently inactivated for cancer to begin. Instead, the team observed that a mutation in one of the BRCA2 genes alone can lead to cancer development without the usual signs of genetic instability seen in fully mutated cells.

Dr. Ashok Venkitaraman, an oncologist and cancer researcher at CSI Singapore, emphasized, “It’s crucial to understand how environmental factors increase cancer risk to take effective preventive measures.”

The researchers focused on individuals inheriting a faulty BRCA2 gene copy and found their cells were more sensitive to methylglyoxal (MGO), a byproduct of glucose breakdown. Elevated MGO levels due to conditions like diabetes can lead to harmful compounds damaging DNA and proteins, which contribute to cancer. “MGO can temporarily disable BRCA2’s tumor-suppressing functions,” Venkitaraman explained. “This disruption can cause cancer-linked mutations in noncancerous cells and patient-derived tissues, as observed in breast and pancreatic cancers in mice.”

While BRCA2 function isn’t permanently impaired, repeated exposure to MGO can lead to accumulating cancer-causing mutations over time, even in individuals with two functioning copies of the gene.

This study, published in Cell, and it underscores the need for further research using larger clinical studies or animal models to explore links between diet, diabetes, and cancer risk. Detecting MGO levels through routine blood tests like HbA1C could potentially serve as a marker for cancer risk.

Dr Venkitaraman believes, “Managing high MGO levels with medication and a healthy diet may offer proactive cancer prevention strategies.”

Ellie 360News.com

What is Your Life Depended on It – One-day sample of a Healthy Diet

Breakfast

  • Smoothie with spinach, berries, banana, and flaxseed
  • Whole-grain toast with avocado

Lunch

  • Quinoa salad with mixed vegetables, chickpeas, and a lemon-tahini dressing
  • Apple or other fresh fruit

Snack

  • Carrot sticks with hummus
  • Handful of nuts (almonds, walnuts)

Dinner

  • Baked salmon with steamed broccoli and sweet potatoes
  • Mixed green salad with a variety of vegetables and olive oil dressing

Dessert

  • Greek yogurt with honey and a sprinkle of cinnamon

Adopting these dietary habits can help reduce the risk of cancer and support overall health. Always consult with a healthcare provider or a registered dietitian before making significant changes to your diet, especially if you have a history of cancer or other health conditions.

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